Plasmid Promiscuity Explains High Endemicity of KPC-2 Among Colombian Enterobacteriaceae
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چکیده
2049. Comparison of the Sepsis-2 and Sepsis-3 Definitions of Sepsis and Their Ability to Predict Mortality in a Prospective Intensive Care Unit Cohort Debra D. Poutsiaka, MD, PhD, FIDSA; Maura Porto, MD; Whitney Perry, MD; Jana Hudcova, MD; David Tybor, PhD, MPH; Susan Hadley, MD, FIDSA; Shira Doron, MD, MS, FIDSA; John Adam Reich, MD; David Snydman, MD, FIDSA and Stanley Nasraway, MD; Division of Geographic Medicine and Infectious Disease, Tufts Medical Center, Boston, Massachusetts, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, Surgical Critical Care, Lahey Hospital and Medical Center, Burlington, Massachusetts, Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, Massachusetts, Department of Surgery, Tufts Medical Center, Boston, Massachusetts
منابع مشابه
Covert dissemination of carbapenemase-producing Klebsiella pneumoniae (KPC) in a successfully controlled outbreak: long- and short-read whole-genome sequencing demonstrate multiple genetic modes of transmission.
Background Carbapenemase-producing Enterobacteriaceae (CPE), including KPC-producing Klebsiella pneumoniae (KPC-Kpn), are an increasing threat to patient safety. Objectives To use WGS to investigate the extent and complexity of carbapenemase gene dissemination in a controlled KPC outbreak. Materials and methods Enterobacteriaceae with reduced ertapenem susceptibility recovered from rectal s...
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Forty-five KPC-producing Enterobacteriaceae strains were isolated from multiple departments in a Chinese public hospital from 2014 to 2015. Genome sequencing of four representative strains, namely Proteus mirabilis GN2, Serratia marcescens GN26, Morganella morganii GN28, and Klebsiella aerogenes E20, indicated the presence of blaKPC-2-carrying IncX6 plasmids pGN2-KPC, pGN26-KPC, pGN28-KPC, and ...
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Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in Europe in the 1990s, are now increasingly being identified at an alarming rate. Although their hydrolysis spectrum may vary, they hydrolyse most β-lactams, including carbapenems. They are mostly of the KPC, VIM, NDM and OXA-48 types. Their prevalence in Europe as reported in 2011 varies significantly from high...
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In order to understand the genetic background and dissemination mechanism of carbapenem resistance and fosfomycin resistance in Enterobacteriaceae isolates, we studied a clinical Escherichia coli strain HS102707 isolate and an Enterobacter aerogenes strain HS112625 isolate, both of which were resistant to carbapenem and fosfomycin and positive for the bla(KPC-2) and fosA3 genes. In addition, a ...
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During the last 30 years there has been a dissemination of plasmid-mediated β-lactamases in Enterobacteriaceae in Brazil. Extended spectrum β-lactamases (ESBL) are widely disseminated in the hospital setting and are detected in a lower frequency in the community setting. Cefotaximases are the most frequently detected ESBL type and Klebsiella pneumoniae is the predominant species among ESBL prod...
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